Definition Of Clo Test By Medical Dictionary. A rapid urease test (CLO test) was used to test the specimen obtained as an indirect method of detecting the presence of H pylori. Prevalence of Helicobacter pylori in family practice patients with refractory dyspepsia: a comparison of tests available in the office What Is A CLO Test?. Also known as rapid urease test, a CLO test is a test that is used to determine the presence of Helicobacter pylori. The test involves placing a biopsy sample on a gel that contains buffers, phenol red, pH indicator and urea or a reaction strip. If there is a presence of Helicobacter pylori, the pH indicator color will change.
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